Emel İPEK1 , Mehtap ÜÇER1 ,Ayşe Sertkaya ÇIKIM2, Sinan TANYOLAÇ1

1Endokrinoloji Diyabet ve Metabolizma Bilim Dalı, İç Hastalıkları Ana Bilim Dalı,İstanbul Bilim Üniversitesi, İstanbul Türkiye
2İnönü Üniversitesi, Tıp Fakültesi, İç Hastalıkları ABD, Endokrinoloi ve Metabolizma Bilim Dalı, Malatya, Türkiye

Keywords: Obesity, serum calcium levels, Insulin resistance, Metabolic syndrome, cardiovascular risk factors.


Obesity prevalance is rapidly increasing all over the world and become a serious health problem. There is a significant correlation between serum calcium levels and body fat mass. It was indicated that when plasma calcium levels increase, body mass index decrease however, insulin, total cholesterol and triglycerides levels increase. In this study, it was investigated the relationship between plasma calcium levels and cardiovascular risk factors and metabolic syndrome parameters in Turkish overweight and obese female patients.

Materiel and Method: 4749 overweight and obese women were evaluated retrospectively. 872 overweight (BMI = 25-30 kg/m2) and 3877 obese (BMI > 30 kg/m2) patients who applied to Istanbul University, Istanbul Faculty of Medicine, Departmant of Internal Medicine, Obesity Outpatient Clinic were evaluated, anthropometric and biochemical parameters were measured. Patients were divided 3 category according to plasma calcium levels. Groups were compared with one-way ANOVA. p<0.05 was accepted as significant.

Results: There were no significant correlation between serum calcium levels and body weight, body fat mass and fat distirbution. Plasma calcium levels significantly associated with cardiovascular risk parameters. In addition, metabolic syndrome indicators and risk parameters were also significantly correlated except high waist circumference.

Our findings indicate that high serum calcium levels associated with obesity-related complication parameters. High risk situation may occur when serum calcium levels high. Elevated calcium levels reflect a metabolic risky situation. It should be cautious to prevent complications while using high-content calcium diets for obese patients treatmant.