Abstract

Diabetes complications usually occur as a result of the change in the balance of free radicals and antioxidant defense mechanisms. That increase damage in cellular organelles and enzymes, thus lipid peroxidation and insulin resistance increase. Melatonin, is an important neurohormone that due to antioxidant property regulate the functions of various organs. In this study the effects of melatonin on diabetes and its complications was investigated. İn many studies beneficial effects have been reported.