The assessment of relationship between uric acid and development of peripheral neuropathy in the patients with type 2 diabetes
Akif Acay1, Serdar Oruç2, Hayri Demirbaş2, Gökhan Yaman1, Ufuk Özuğuz3
1Afyon Kocatepe Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Afyonkarahisar
2Afyon Kocatepe Üniversitesi Tıp Fakültesi, Nöroloji Anabilim Dalı, Afyonkarahisar
3Afyon Kocatepe Üniversitesi Tıp Fakültesi, Endokrinoloji ve Metabolizma Hastalıkları Bilim Dalı, Afyonkarahisar
Keywords: Uric acid, diabetes mellitus, diabetic peripheral neuropathy
Introduction: In terms of prevention and therapy, in patients with diabetes mellitus it is important to foresee chronic complications as neuropathy. In this study we aimed to evaluate the contribution of uric acid to development of neuropathy and uric acid of the patients with type 2 diabetic with and without neuropathy.
Material and methods: 90 patients with diabetic peripheral neuropathy, 92 patients with diabetes mellitus but without chronic complications and 90 healthy volunteers were included in the study. Serum HbA1c, C-reactive protein, uric acid, total cholesterol, LDL, HDL cholesterol, creatinin and fasting blood glucose levels were analyzed.
Result: The mean age and gender of groups of patient and control were similar. Besides, in the patient groups, therapy options, duration of the illness, fasting blood glucose, and HbA1c were statistically similar, too. Fasting blood glucose, HbA1c, uric acid and trigliceride levels of the patient groups were significantly higher, whereas HDL levels were significantly lower than control group. When the patient groups were compared with each other, although it was not statistically significant, C-reactive protein, creatinin and uric acid levels were higher in the patients with neuropathy in comparison with the diabetic group.
Discussion: Our results were partly similar with the other studies. This may be due to the diversity of the regional nourishment and genetically different serum levels of the uric acid. We believe that further studies are needed to exhibit the role of uric acid levels in the development of neuropath.