Role of Endocrine Disorders in Recurrent Early Pregnancy Loss
Ercan BAŞTU1, Mehmet Fırat MUTLU2, Özlem DURAL3, Faruk BUYRU1
Keywords: thyroid autoantibodies, polycystic ovarian syndrome, luteal phase defect, recurrent pregnancy loss
Existence of a link between endocrine disorders and recurrent pregnancy loss (RPL) has been well established. Since embryo attachment and early implantation are managed by the local hormonal milieu, endocrine-related pregnancy failures usually occur during early gestation. Endocrine abnormalities, such as thyroid disorders, luteal phase defects and polycystic ovary syndrome, are commonly associated with RPL. In this review we discuss new concepts in the pathophysiology and treatment of these diseases and their effects on pregnancy maintenance and outcome.