Mustafa Donmez1, Arif Hakan Demirel2, Serdar Kuru3, Muruvvet Ozdiken4

Keywords: Cholelitiasis, Metabolic syndrome, Obesity


Introductıon: The purpose of this study is to establish the rate of metabolic syndrome and the value of the anthropemetric measures in etiology of the cholelitiasis.
Method: One hundred elective cholecystectomy inpatients and 50 outpatients with complaints other than cholelitiasis were included in the study. The height, weight, waist circumference, hip circumference, and blood pressures were measured. Serum glucose, insulin, HbA1c, uric acid, total cholesterol, triglyceride, HDL, and LDL cholesterol levels were determined. HOMA value was calculated to evaluate insulin resistance. The patients were assessed in terms of metabolic syndrome according to NCEP/ATP III criteria.
Results: The average number of the delivery was higher in the cholelitiasis cases than the control group (p=0.013). The high waist/hip ratio has been shown to have effects on cholelitiasis development in both sexes (p<0.05). The mean waist circumference was higher in the females with cholelitiasis as compared to women without cholelitiasis (p=0.0001). The risk of cholelitiasis was increased in the presence of diabetes mellitus, or hipertension, or hiperlipide mia (p=0.003). The average HOMA levels was found to be higher in the cholelitiasis cases significantly, and cholelitiasis risk was 1.92-fold higher in the patients with high HOMA levels. The risk of cholelitiasis was increased 2.43-fold higher in the patients with metabolic syndrome (p=0.015).
Conclusion: Cholelitiasis development was significantly associated with metabolic syndrome presence, high waist/hip ratio, antihypertensive and antidiabetic drug usage in both sexes, and high waist circumference and high delivery number in females.