Anterior pitutary insufficiency: single centre experience
Elif Önder1, Yusuf Aydin1, Murat Erdoğan2, Fatih Ermiş2, Hülya Coşkun2, Mücahit Gür2, Leyla Yılmaz Aydın3, Seher Kır2
1Düzce Üniversitesi Tıp Fakültesi Endokrinoloji ve Metabolizma Hastalıkları Bölümü, Düzce
2Düzce Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, Düzce
3Düzce Üniversitesi Tıp Fakültesi Göğüs Hastalıkları Anabilim Dalı, Düzce
Keywords: Pituitary, insufficiency, panhypopituitarizm
Objective: Objective: Pituitary insufficiency is a rarely seen clinical condition but it quitely deteriorates the quality of life in case of hormone deficiency. This study was designed to determine the frequency, causes and general charecteritics of pituitary insufficiency in our endocrinology outpatiet clinic.
Methods: In the study, 10.000 patients, who were referred to the endocrinology outpatient clinic between the years of 2009-2013, were included. Files of these patients were evaluated retrospectively. The diagnosis of pituitary insufficiency was based on the baseline hormone levels, the dynamic tests (insulin hypoglycemia test, L-Dopa test, GnRH test) and imaging studies results. Patients were classified according to the investigations as isolated growth hormone (GH) deficiency, isolated FSH-LH deficiency, GH and FSH-LH deficiency, GH, FSH, LH and TSH deficiency and panhipopituitarizim (GH, FSH, LH, TSH and ACTH deficiency).
Results: The mean age of patients was 43.00 ± 15.00 in the study, 40 patients (62.5%) were male and 24 (37.5%) were female. In our study, frequency of pituitary insufficiency was 0.64% in endocrinology outpatiet clinic. In our study, pituitary surgery was the most common cause of the pituitary insufficiency. Panhypopituitarizm was detected in the 27 of the 64 patients included in the study. Most frequently seen subgroup of the pituitary insufficiency was panhypopituitarism (0.27%) in females. In men, most frequently seen subgroup of the pituitary insufficiency was isolated FSH-LH deficiency and the panhypopituitarism was in the second state.
Conclusion: In our study, frequency of pituitary insufficiency was 0.64% in endocrinology outpatiet clinic while the ratio of panhypopituitarism was 0.27%. The most common cause of the pituitary insufficiency was detected as the surgical procedures for the pituitary gland.