Abstract

Background: Although thyroid nodules are common in society, fine needle aspiration biopsy of this nodule is an important step in distinguishing wheather it’s benign or malignant. In our study, we aimed to investigate the effect of the trauma in thyroid gland on thyroid hormones and thyroglobulin during this process.
Material method: This study was conducted between 2012-2014 on total of 114 patient. Prior to procedure thyroid function tests and routine ultrasonography (USG) were performed. To examine their thyroid stimulating hormone (TSH), free T3, free T4 and Thyroglobulin (TG) venous blood samples were taken from all the patients 30 minutes prior to and 120 minutes after the biopsy.
Results: Increments in TG levels 30 minutes and 120 minutes after the biopsy compared to thyroglobulin (TG) levels immediately prior to the biopsy determined as statistically significant in advanced level (p<0.01). There was no statistically significant difference determined between the TSH levels immediately prior to biopsy, 30 min. and 120 min. after the biopsy (p>0.05). There was no statistically significant difference determined between the fT4 levels immediately prior to biopsy, 30 min. and 120 min. after the biopsy (p>0.05). There was no statistically significant difference determined between the fT3 levels immediately prior to biopsy, 30 min. and 120 min. after the biopsy (p>0.05).
Conclusion: Via FNAB distinction between benign and malignant lesions can be made which could prevent unnecessary surgical intervention and surgical technique can be chosen according to FNAB results. Besides, it is important to have blood samples taken and assessed prior to FNAB initiative to prevent false positive and negative evaluation of TG and thyroid hormone levels which provide great benefit on diagnosis, treatment and follow-up.