Hyperparathyroidism relationship in the etiology of colonic car- cinoma: huge parathyroid adenoma
Alican Güreşin1, Gökhan Pösteki1, Sertaç Ata Güler1, Turgay Şimşek1, Emre Özcan2, Nuh Zafer Cantürk1
1Kocaeli Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Kocaeli
2Kocaeli Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı, Kocaeli
Keywords: Huge parathyroid adenoma, Sigmoid colon carcinoma, Hyperparathyroidism, Hypercalcemia
Primary hyperparathyroidism (PHPT) is a common endocrine disorder. PHPT is usually characterized by nonspecific symptoms such as fatigue, mood changes, and cognitive changes. The diagnosis is made by ascending parathyroid gland or upper limit of normal with total or ionized calcium in the laboratory. Criteria for surgical treatment have been established. The most appropriate treatment for patients with symptomatic and asymptomatic PHPT is parathyroidectomy. Calcium is a potent anticarcinogenic agent. It is known that PHPT is associated with malignancy. Decreased intracolonic calcium (Ca) due to increased vitamin D (vit D) levels may play a role in colorectal carcinogenesis.
In our case, the patient had been diagnosed with sigmoid colon cancer and at the same time giant parathyroid adenoma was detected and increased parathormone level was detected. Depending on the level of parathormone, vitamin D is thought to be related in the etiology of colon cancer.
Although the PHPT and colon cancer association is not often conceivable, diagnosis in hypercalcemia or in patients with colon cancer may be easier to achieve. It should also be noted that although hypercalcemia detected in a cancer-diagnosed patient may often be associated with paraneoplastic processes or bone metastasis, hypercalcemia in patients may contribute to the carcinogenic process.