Akif Acay1, Ahmet Ahsen1, İlker Polat2, Memnune Sena Ulu1, Salim Susuz2, Mehtap Beker Acay3, Ufuk Özuğuz4

Keywords: Hashimoto's thyroiditis, neutrophil-lymphocyte-ratio, inflammation


Aim: The aim of this study is to evaluate the relations between NLR (which is a sign of sub-clinical inflammation in patients with Hashimoto thyroid) and thyroid functions, autoimmunity and sonographical properties.
Material and Method: The study included 40 patients with HT diagnosis and 25 healthy voluntary. The neutrophile, lymphocyte, ESH, CRP, TSH, sT4,sT3, anti Tg and anti TPO values were measured. NLR was calculated with neutrophile and lymphocyte values. Thyroid ultrasound was applied in order to evaluate the thyroid parenchyma heterogeneity, and thyroid dimensions were measured.
Findings: The age averages of patient and control groups were similar. Significant difference was detected between groups in terms of TSH, anti TPO and anti Tg levels. (Respectively P=0.04, P˂0.001 and P˂0.001). While CRP level was 0.44±0.31 in the patient group, it was 0.26±0.1 in control group and the difference was assumed to be significant. (P=0.003). No significant difference between groups was detected in terms of ESR and NLR. Significant difference was detected between groups in terms of parenchyma heterogeneity, border irregularity, and pseudo-nodule existence. (P˂0.001), (P=0.003), (P=0.01). Significant positive correlation was detected between NLR and CRP (r=0.31, P=0.04).
Conclusion: In this study where we research the importance of NLR for detecting inflammation in patients with HT, while a relation between HT and CRP was detected, no significant relation with NLR was detected. However the existence of positive correlation between CRP and NLR shows us that more prospective studies about this issue with more patients are required.